Embedded System Based Automated Drug Delivery Unit and MicroFluidics for drug discovery

Abstract: Drug dosing is a technique that is done to cure the diseases through proper prescription and control of drugs that have been identified to the corresponding disease based on diagnosis. Drug dosing is a very critical and challenging step that needs to be correctly monitored and prescribed by the doctor. Drug dosing in human beings also depends upon size, area, weight and volume of the recipient. There are various ways of drug dosing, targeted therapies are the current state of the art and are probably the best predictor in terms of perceiving the dosing. Nanobio systems are used for targeted therapies. Food and Drug Administration (FDA) has recommended the use of nanobio systems for targeted therapy and drug dosing but they do not have many models. In reality very few exist. With limitations in availability of common platforms for development and validation of automated systems there is a need for a new methodology or integration of multiple platforms to integrate biosensors, expert system and drug diffusion unit. Prostate cancer is one of the major cancers that is affecting men in India. After lung cancer prostate cancer has caused large number of deaths in India. Nanowire is the biosensor used for detection of cancers. In this paper, we present a design of nanowire array sensor for prostate cancer detection. A sensor array of 8 x 8 elements is designed to capture the PSA present in the blood that helps in detecting the presence of prostate cancer. An experimental setup has been developed using the biosensors lab from Nanohub.org. Based on the experimental setup the nanowire sensor is characterized for PSA detection. The sensitivity of detection is increased by use of sensor array. The Automatic drug delivery system is based on bio sensors. However the bio sensors are not under the purview of this project. To create a real time model, the sensors were simulated. Employing Servo motors connected to a voltage divider network simulated sensors. Eight voltage dividers were employed wherein, in each of the dividers; a fixed resistor & a potentiometer were used. The servo motor moves the wiper of pot and thus varies the voltage output on the ADC channel.

Keywords: Prostate specific antigen, bio sensors, nano wire sensors, Bio markers, DNA, Micro Fluidics