Abstract: Diabetic Nephropathy(DN) is one of fast growing disease. The survey tells that 41312 peoples are under treatment of end stage renal disease in 2001.$22.8 are spend to take care of them.15% national health budget is spend on Diabetic Nephropathy if it at last stage that end stage renal disease(ESRD) then it is serious so the proposed research will helpful because here we are trying to detect DN at early stage by analyzing capillaries basement membrane and implementation will be done in Python a new approach for image processing as this research will contain image data of various DN patients.

Keywords: DN, Glomeruli, ESRD, Nephron