Literature Survey on Framework for Generating MS-MS Spectra for MS Spectrometry Data

Abstract: It is no understatement that mass spectrometry is revolutionizing biological studies. Current mass spectrometers are capable of a tremendous throughput, and can survey thousands of proteins from complex sample mixtures. The most commonly applied mass spectrometry techniques is Tandem-MS. This high-throughput technology generates huge amounts of data. Databases are critical for recording and carefully storing this data. This project considers data acquisition performed by a vendor specific software that generates a file annotating the mass spectra and look up file. The mass spectra data file is given as an input to Hadoop. Here the file is divided into smaller chunks of large file based on the requirements. These smaller chunks are then compared with look up file and required analytics is performed. And the output is given in an interactive visualization environment.

Keywords: Mass Spectrometry, Hadoop, Database, Tandem-MS, Data Acquisition.